Scientific Studies

General Notes On Scientific Health Benefits:

The majority of these studies have been conducted in laboratories on animals or in clinical studies on humans or human tissues. The studies we have linked to have all been published in reputable magazines or journals that the health and science industry uses to provide their results. Animal studies do not always correlate to human results, but they are a positive sign that the product is beneficial. These mushrooms have been used in Eastern Medicine and Indigenous Americans for hundreds of years before modern medicine was available. It is unlikely they would continue to consume medicinal mushrooms for generations if they did not provide helpful benefits. Our ancestors were smart enough to know if your patient ate something and then died, you should try something else next time.

 

The Mushrooms

Cordyceps (CORDACEX!) Scientific Studies

Studies In Which Cordyceps Increased Sexual Desire (both sexes!), Increased Fertility, and Provides Better Erections. Some studies are with animals and some are with humans. (Charisma +6)

  1. Jiraungkoorskul K, Jiraungkoorskul W. Review of Naturopathy of Medical Mushroom, Ophiocordyceps Sinensis, in Sexual Dysfunction. Pharmacogn Rev. 2016;10(19):1–5. doi:10.4103/0973-7847.176566
  2. Ji DB, Ye J, Li CL, Wang YH, Zhao J, Cai SQ. Antiaging effect of Cordyceps sinensis extract. Phytother Res. 2009 Jan;23(1):116-22. doi: 10.1002/ptr.2576. PubMed PMID: 18803231.  (A little side note on this study, it’s weird that someone has the job of measuring rat erections)
  3. In-Pyo Hong∗, Yong-Soo Choi, Soon-Ok Woo, Sang-Mi Han, Hye-Kyung Kim, Man-Young Lee, Myung-Ryul Lee, and Richard A. Humber. Effect of Cordyceps militaris on Testosterone Production in Sprague-Dawley Rats. Int. J. Indust. Entomol. Vol. 23, No. 1, 2011, pp. 143~146
  4. Panda AK, Swain KC. Traditional uses and medicinal potential of Cordyceps sinensis of Sikkim. J Ayurveda Integr Med. 2011;2(1):9–13. doi:10.4103/0975-9476.78183
  5. Huang BM, Hsiao KY, Chuang PC, Wu MH, Pan HA, Tsai SJ. Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. Biol Reprod. 2004 May;70(5):1358-64. Epub 2004 Jan 7. PubMed PMID: 14711788.
  6. Manabe N, Azuma Y, Sugimoto M, Uchio K, Miyamoto M, Taketomo N, Tsuchita H, Miyamoto H. Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism and blood flow in dietary hypoferric anaemic mice. Br J Nutr. 2000 Feb;83(2):197-204. PubMed PMID: 10743500.
  7. Jiraungkoorskul K, Jiraungkoorskul W. Review of Naturopathy of Medical Mushroom, Ophiocordyceps Sinensis, in Sexual Dysfunction. Pharmacogn Rev. 2016 Jan-Jun;10(19):1-5. doi: 10.4103/0973-7847.176566. Review. PubMed PMID: 27041868; PubMed Central PMCID: PMC4791983.
  8. Zhu, J. et al. The Scientific Rediscovery of an Ancient Chinese Herbal Medicine: Cordyceps sinensis The Journal Of Alternative And Complementary Medicine [part 1]Volume 4, Number 3, 1998, pp. 289—303 [part 2] Volume 4, Number 4, 1998, pp. 429 – 457.

Studies In Which Cordyceps Boosted Exercise Performance (Stamina +4, Strength +2)

  1. Xu YF. Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming, Int J Med Mushrooms. 2016;18(12):1083-1092. doi: 10.1615/IntJMedMushrooms.v18.i12.30.
  2. Akira Nagata, Taeko Tajima, and Masayuki Uchida, Supplemental Anti-Fatigue Effects of Cordyceps Sinensis, Jpn. J. Phys. Fitness Sports Med. 2006
  3. Yi, X., Xi-zhen, H. & Jia-shi, Z. Chin. Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers, J. Integr. Med. (2004) 10: 187. 
  4. Hirsch KR, Smith-Ryan AE, Roelofs EJ, Trexler ET, Mock MG. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl. 2017;14(1):42–53. doi:10.1080/19390211.2016.1203386
  5. Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. J Altern Complement Med. 2010;16(5):585–590. doi:10.1089/acm.2009.0226

Ability To Fight Cancer In Laboratory Studies Of Animal and Human Tissues (Health +2)

  1. Vasiljevic JD, Zivkovic LP, Cabarkapa AM, Bajic VP, Djelic NJ, Spremo-Potparevic BM. Cordyceps sinensis: Genotoxic Potential in Human Peripheral Blood Cells and Antigenotoxic Properties Against Hydrogen Peroxide by Comet Assay. Altern Ther Health Med. 2016 Jun;22 Suppl 2:24-31.
  2. Bizarro A, Ferreira IC, Soković M, van Griensven LJ, Sousa D, Vasconcelos MH, Lima RT. Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21. Molecules. 2015 Jul 31;20(8):13927-40. doi: 10.3390/molecules200813927. PubMed PMID: 26263965; PubMed Central PMCID: PMC6332316.
  3. Lee HH, Lee S, Lee K, Shin YS, Kang H, Cho H. Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis. Daru. 2015 Jul 4;23:35. doi: 10.1186/s40199-015-0117-6. PubMed PMID: 26141646; PubMed Central PMCID: PMC4491205.
  4. Nakamura K, Yamaguchi Y, Kagota S, Kwon YM, Shinozuka K, Kunitomo M. Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice. Jpn J Pharmacol. 1999 Mar;79(3):335-41. PubMed PMID: 10230862.
  5. Ng TB, Wang HX. Pharmacological actions of Cordyceps, a prized folk medicine. J Pharm Pharmacol. 2005 Dec;57(12):1509-19. Review. PubMed PMID: 16354395.
  6. Yamaguchi N, Yoshida J, Ren LJ, Chen H, Miyazawa Y, Fujii Y, Huang YX, Takamura S, Suzuki S, Koshimura S, et al. Augmentation of various immune reactivities of tumor-bearing hosts with an extract of Cordyceps sinensis. Biotherapy. 1990;2(3):199-205. PubMed PMID: 2206772.
  7. Liu WC, Chuang WL, Tsai ML, Hong JH, McBride WH, Chiang CS. Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia. Exp Biol Med (Maywood). 2008;233(4):447–455. doi:10.3181/0708-RM-230

Anti-Aging Effects Found In Studies With Animals (Stamina +4, Health +2)

  1. Ji DB, Ye J, Li CL, Wang YH, Zhao J, Cai SQ. Antiaging effect of Cordyceps sinensis extract. Phytother Res. 2009 Jan;23(1):116-22. doi: 10.1002/ptr.2576. PubMed PMID: 18803231.
  2. Li XT, Li HC, Li CB, Dou DQ, Gao MB. Protective effects on mitochondria and anti-aging activity of polysaccharides from cultivated fruiting bodies of Cordyceps militaris. Am J Chin Med. 2010;38(6):1093-106. PubMed PMID: 21061463.
  3. Xiao JH, Xiao DM, Chen DX, Xiao Y, Liang ZQ, Zhong JJ. Polysaccharides from the Medicinal Mushroom Cordyceps taii Show Antioxidant and Immunoenhancing Activities in a D-Galactose-Induced Aging Mouse Model. Evid Based Complement Alternat Med. 2012;2012:273435. doi: 10.1155/2012/273435. Epub 2012 Mar 29. PubMed PMID: 22536281; PubMed Central PMCID: PMC3321445.
  4. Ning-Zhi Tan, Jamie L Barger, Yan Zhang, Scott B Ferguson, Zi-Mei Wu, Tomas A Prolla, Mark Bartlett, and Jia-Shi Zhu. The lifespan-extending effect of Cordyceps sinensis Cs-4 in normal mice and its molecular mechanisms. The FASEB Journal 2011 25:1_supplement, 599.1-599.1
  5. Zou Y, Liu Y, Ruan M, et al. Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress. Int J Mol Med. 2015;36(4):939–946. doi:10.3892/ijmm.2015.2296

Heart Benefits Found In Laboratory Studies Of Animals (Stamina +4, Health +2)

  1. Liu X, Zhong F, Tang XL, et al. Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis. Acta Pharmacol Sin. 2014;35(5):697–706. doi:10.1038/aps.2013.186
  2. Yan XF, Zhang ZM, Yao HY, Guan Y, Zhu JP, Zhang LH, Jia YL, Wang RW. Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors. Phytother Res. 2013 Nov;27(11):1597-604. doi: 10.1002/ptr.4899. Epub 2012 Nov 28. PubMed PMID: 23192916.
  3. Gao J, Lian ZQ, Zhu P, Zhu HB. Lipid-lowering effect of cordycepin (3′-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats. Yao Xue Xue Bao. 2011 Jun;46(6):669-76. PubMed PMID: 21882527.
  4. Guo P, Kai Q, Gao J, Lian ZQ, Wu CM, Wu CA, Zhu HB. Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J Pharmacol Sci. 2010;113(4):395-403. PubMed PMID: 20724804.
  5. Jong-Ho Koh, Jin-Man Kim, Un-Jae Chang, Hyung-Joo Suh. Hypocholesterolemic Effect of Hot-Water Extract from Mycelia of Cordyceps sinensis. Biological and Pharmaceutical Bulletin 2003 Volume 26 Issue 1 Pages 84-87

In Studies Cordyceps Has Been Shown To Decrease Inflammation (Strength +2, Health +2)

  1. Kuo YC, Tsai WJ, Shiao MS, Chen CF, Lin CY. Cordyceps sinensis as an immunomodulatory agent. Am J Chin Med. 1996;24(2):111-25. PubMed PMID: 8874668.
  2. Kim KM, Kwon YG, Chung HT, Yun YG, Pae HO, Han JA, Ha KS, Kim TW, Kim YM. Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-kappaB activation. Toxicol Appl Pharmacol. 2003 Jul 1;190(1):1-8. PubMed PMID: 12831777.
  3. Weng SC, Chou CJ, Lin LC, Tsai WJ, Kuo YC. Immunomodulatory functions of extracts from the Chinese medicinal fungus Cordyceps cicadae. J Ethnopharmacol. 2002 Nov;83(1-2):79-85. PubMed PMID: 12413710.
  4. Park SY, Jung SJ, Ha KC, et al. Anti-inflammatory effects of Cordycepsmycelium (Paecilomyces hepiali, CBG-CS-2) in Raw264.7 murine macrophages. Orient Pharm Exp Med. 2015;15(1):7–12. doi:10.1007/s13596-014-0173-3
  5. Won SY, Park EH. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. J Ethnopharmacol. 2005 Jan 15;96(3):555-61. Epub 2004 Dec 10. PubMed PMID: 15619578.

Lion’s Mane Scientific Studies

Studies Have Shown That Lion’s Main Can Improve Brain Function and Decreases Memory Loss (Intelligence +6)

  1. Lai PL, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54. PubMed PMID: 24266378.
  2. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009 Mar;23(3):367-72. doi: 10.1002/ptr.2634. PubMed PMID: 18844328.
  3. Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N. Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Biomed Res. 2011 Feb;32(1):67-72. PubMed PMID: 21383512.

Lion’s Mane May Be Effective In Combating Dementia/Alzheimer’s Disease (Intelligence +6, Health +4)

  1. Tsai-Teng T, Chin-Chu C, Li-Ya L, Wan-Ping C, Chung-Kuang L, Chien-Chang S, Chi-Ying HF, Chien-Chih C, Shiao YJ. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice. J Biomed Sci. 2016 Jun 27;23(1):49. doi: 10.1186/s12929-016-0266-z. PubMed PMID: 27350344; PubMed Central PMCID: PMC4924315.
  2. Zhang J, An S, Hu W, et al. The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model. Int J Mol Sci. 2016;17(11):1810. Published 2016 Nov 1. doi:10.3390/ijms17111810
  3. Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complement Altern Med. 2016;16:170. Published 2016 Jun 7. doi:10.1186/s12906-016-1154-5

Lion’s Mane Has Shown In Studies That It Could Reduce Anxiety And Depression (Charm +2)

  1. Yao W, Zhang JC, Dong C, Zhuang C, Hirota S, Inanaga K, Hashimoto K. Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration. Pharmacol Biochem Behav. 2015 Sep;136:7-12. doi: 10.1016/j.pbb.2015.06.012. Epub 2015 Jul 4. PubMed PMID: 26150007.
  2. Chiu CH, Chyau CC, Chen CC, Lee LY, Chen WP, Liu JL, Lin WH, Mong MC. Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. Int J Mol Sci. 2018 Jan 24;19(2). pii: E341. doi: 10.3390/ijms19020341. PubMed PMID: 29364170; PubMed Central PMCID: PMC5855563.
  3. Ryu S, Kim HG, Kim JY, Kim SY, Cho KO. Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain. J Med Food. 2018 Feb;21(2):174-180. doi: 10.1089/jmf.2017.4006. Epub 2017 Nov 1. PubMed PMID: 29091526.
  4. Brandalise F, Cesaroni V, Gregori A, et al. Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice. Evid Based Complement Alternat Med. 2017;2017:3864340. doi:10.1155/2017/3864340
  5. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010 Aug;31(4):231-7. PubMed PMID: 20834180.

Lions Mane May Protect Against Ulcers (Health +4)

  1. Jiang S, Wang S, Sun Y, Zhang Q. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals. Appl Microbiol Biotechnol. 2014 Sep;98(18):7661-70. doi: 10.1007/s00253-014-5955-5. Epub 2014 Jul 29. Review. PubMed PMID: 25070597.
  2. Wang M, Konishi T, Gao Y, Xu D, Gao Q. Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes). Int J Med Mushrooms. 2015;17(11):1055-60. PubMed PMID: 26853960.
  3. Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2016 May 13;183:54-58. doi: 10.1016/j.jep.2015.09.004. Epub 2015 Sep 11. PubMed PMID: 26364939.
  4. Shang X, Tan Q, Liu R, Yu K, Li P, Zhao GP. In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion’s Mane mushroom, Hericium erinaceus (higher Basidiomycetes). Int J Med Mushrooms. 2013;15(2):165-74. PubMed PMID: 23557368.
  5. Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, Sabaratnam V. Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: 10.1155/2013/492976. Epub 2013 Nov 5. PubMed PMID: 24302966; PubMed Central PMCID: PMC3835629.
  6. Qin M, Geng Y, Lu Z, Xu H, Shi JS, Xu X, Xu ZH. Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis. Int J Med Mushrooms. 2016;18(3):227-34. doi: 10.1615/IntJMedMushrooms.v18.i3.50. PubMed PMID: 27481156.
  7. Diling C, Xin Y, Chaoqun Z, Jian Y, Xiaocui T, Jun C, Ou S, Yizhen X. Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota. Oncotarget. 2017 Sep 6;8(49):85838-85857. doi: 10.18632/oncotarget.20689. eCollection 2017 Oct 17. PubMed PMID: 29156761; PubMed Central PMCID: PMC5689651.

Animal Testing Shows Lion’s Mane Helps Control Diabetes Symptoms By Keeping Blood Sugar Low (Health +4)

  1. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. Published 2013 Oct 3. doi:10.1186/1472-6882-13-253
  2. Wu T, Xu B. Antidiabetic and antioxidant activities of eight medicinal mushroom species from China. Int J Med Mushrooms. 2015;17(2):129-40. PubMed PMID: 25746618.
  3. Yi Z, Shao-Long Y, Ai-Hong W, et al. Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in RatsEvid Based Complement Alternat Med. 2015;2015:595480. doi:10.1155/2015/595480

Chaga (BOOMCHAGA!) Scientific Studies

These reference links are directly from the Memorial Sloan Kettering Cancer Center article on Chaga:

Potential For Fighting Cancer Due To The Extremely High Level of Anti-oxidants In Chaga (Health +8, Immunity +4)

  1. Youn MJ, Kim JK, Park SY, et al. Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells. World J Gastroenterol. Jan 28 2008;14(4):511-517.
  2. Lee SH, Hwang HS, Yun JW. Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells. Phytother Res. Apr 15 2009.
  3. Youn MJ, Kim JK, Park SY, et al. Potential anticancer properties of the water extract of Inonotus[corrected] obliquus by induction of apoptosis in melanoma B16-F10 cells. J Ethnopharmacol. Jan 21 2009;121(2):221-228.
  4. Ham SS, Kim SH, Moon SY, et al. Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract. Mutat Res. Jan 10 2009;672(1):55-59.
  5. Ning X, Luo Q, Li C, et al. Inhibitory effects of a polysaccharide extract from the Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), on the proliferation of human neurogliocytoma cells. Int J Med Mushrooms. 2014;16(1):29-36.
  6. Kang JH, Jang JE, Mishra SK, et al. Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the beta-catenin pathway in colorectal cancer. J Ethnopharmacol. Sep 15 2015;173:303-312.
  7. Lee HS, Kim EJ, Kim SH. Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells. Nutr Res Pract. Apr 2015;9(2):111-116.
  8. Zhao LW, Zhong XH, Yang SY, et al. Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells. Asian Pac J Cancer Prev. 2014;15(7):3195-3199.
  9. Sun Y, Yin T, Chen XH, et al. In vitro antitumor activity and structure characterization of ethanol extracts from wild and cultivated Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilat (Aphyllophoromycetideae). Int J Med Mushrooms. 2011;13(2):121-130.
  10. Baek J, Roh HS, Baek KH, et al. Bioactivity-based analysis and chemical characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in human lung adenocarcinoma cells. J Ethnopharmacol. Oct 5 2018;224:63-75.
  11. Ham SS, Kim SH, Moon SY, et al. Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract. Mutat Res. Jan 10 2009;672(1):55-59.

Study Showing Anti-inflammatory Effects (Health +8, Immunity +4)

  1. Park YM, Won JH, Kim YH, et al. In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus. J Ethnopharmacol. Oct 3 2005;101(1-3):120-128.

Anti-diabetic Effects (Immunity +4)

  1. Sun JE, Ao ZH, Lu ZM, et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol. Jun 19 2008;118(1):7-13.
  2. Ying YM, Zhang LY, Zhang X, et al. Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus. Phytochemistry. Dec 2014;108:171-176.
  3. g J, Hu W, Li L, et al. Antidiabetic activities of polysaccharides separated from Inonotus obliquusvia the modulation of oxidative stress in mice with streptozotocin-induced diabetes. PLoS One.2017;12(6):e0180476. doi: 10.1371/journal.pone.0180476

Help For Inflammatory Bowel Disease (irritable bowel) (Health +8, Immunity +4)

  1. Najafzadeh M, Reynolds PD, Baumgartner A, Jerwood D, Anderson D. Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease.Biofactors. 2007;31(3-4):191-200.
  2. Mishra SK, Kang JH, Kim DK, et al. Orally administered aqueous extract of Inonotus obliquusameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice. J Ethnopharmacol. Sep 28 2012;143(2):524-532.

Anti-viral Effects (herpes simplex) (Immunity +4)

  1. n HH, Yu XT, Li T, et al. Aqueous extract from a Chaga medicinal mushroom, Inonotus obliquus(higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion. Int J Med Mushrooms. 2013;15(1):29-38.

Chaga Improves Brain Function Of Mice (Stamina +2)

  1. Giridharan VV, Thandavarayan RA, Konishi T. Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus – a medicinal mushroom. Food Funct. Jun 2011;2(6):320-327.

In A Study Mice Had Less Physical Fatigue After Being Administered Chaga (Stamina +2)

  1. Yue Z, Xiuhong Z, Shuyan Y, et al. Effect of Inonotus Obliquus Polysaccharides on physical fatigue in mice. J Tradit Chin Med. Aug 2015;35(4):468-472.